SnapShot: Ca2+-Calcineurin-NFATSignaling

SnapShot: Ca2+-Calcineurin-NFATSignaling

SnapShot: Ca2+-Dependent Transcription in Neurons

Calcineurin links Ca2+ dysregulation with brain aging.

Brain aging is associated with altered Ca(2+) regulation. However, many Ca(2+) signal transduction mechanisms have not been explored in the aged brain. Here, we report that cytosolic expression and activity of the Ca(2+)-dependent protein phosphatase calcineurin (CaN) increases in the hippocampus during aging. CaN changes were paralleled by increased activation, but not expression, of CaN-regul...

Calcineurin-independent inhibition of mitochondrial Ca2+ uptake by cyclosporin A.

1. Cyclosporin A (CsA) is a widely used compound because of its potent immunosupressive properties, derived mainly from the inhibition of calcineurin, and also because of its ability to block the mitochondrial permeability transition pore (PTP). This second effect has been involved in the protection against apoptosis mediated by release of mitochondrial factors. We show here that CsA (1-10 micr...

Fingolimod (FTY720) Stimulates Ca2+/Calcineurin Signaling in Fission Yeast

Fingolimod hydrochloride (FTY720) is the first in class of sphingosine 1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis via down-regulation of G protein-coupled S1P receptor 1 by its phosphorylated form (FTY720-P). Many studies have revealed that FTY720 exerts various biological effects, including antitumor activities, angiogenesis inhibition, Ca(2+) mobilization and ap...